Entries in Dan Murphy (2)

Saturday
Jan192013

Reverse Causality and Whiplash Injury: Three Recent Reviews

Dan Murphy, DC—

Private Practice of Chiropractic;
Diplomate American Board of Chiropractic Orthopedist;
Faculty Life Chiropractic College West;
Vice President ICA 2003-2009;

ICA Chiropractor of the Year 2009

 

INTRODUCTION

            Reverse causality refers to a direction of cause-and-effect contrary to a common presumption. Reverse causality is cause and effect in reverse. That is to say the effects precede the cause. The problem is when the assumption is A causes B when the truth may actually be that B causes A.

            It is usually stated in published studies, by insurance companies, and by their representatives (lawyers, claims adjusters, IME doctors, etc.) that injured patients who seek compensation (ask for compensation, hire a lawyer, etc.)(A), have worse health outcomes and slower recovery rates (B).

However, such adverse health outcomes do not consider or evaluate the concept of Reverse Causality: “slower recovery (B) leads individuals to claim, seek legal advice, and litigate (A).”

The contemporary leaders in the research pertaining to injury compensation, health outcomes, and Reverse Causality are Natalie Spearing and colleagues from the University of Queensland in Australia. In 2011, they published a study in the journal Injury, titled (1):

  • Is compensation “bad for health”?

            These authors performed a systematic meta-review on this topic, which constituted the most comprehensive review pertaining to compensation and health outcomes through the publication date. In this study, the authors used 11 studies that met their stringent inclusion criteria and noted that 9 of them were of low quality and suffered from a number of methodological flaws.

The studies presented in this review support these concepts:

•           Studies that claim that those suffering from chronic problems following whiplash injury do so in hope of gaining financial compensation have methodological flaws.

•           The best methodologically done studies show there is no association between litigation/compensation and recovery from whiplash injury.

•           It is wrong to claim that chronic whiplash symptoms are primarily the consequence of litigation and desire for monetary gain.

            These authors conclude: “There is a common perception that injury compensation has a negative impact on health status among those with verifiable and non-verifiable injuries, and systematic reviews supporting this thesis have been used to influence policy and practice. However, such reviews are of varying quality and present conflicting conclusions.” The contention that “compensation is ‘bad for health’, should be viewed with caution.”

            In June 2012, Natalie Spearing and colleagues published another on-topic study in the journal Pain, titled (2):

  • Does injury compensation lead to worse health after whiplash? 

            In this article, Spearing and colleagues introduce the concept of Reverse Causality Bias in the evaluation of the relationship between compensation and health outcome. They note that Reverse Causality Bias occurs when the results of a study are interpreted to mean that whiplash-injured people who hire lawyers to obtain compensation have worse health recovery outcomes; when in fact it may actually mean that whiplash-injured people with greater injuries, more pain and more disability are the ones who seek lawyers to help them obtain the benefits they need.

            The authors note that many believe that compensation after whiplash injury does more harm than good. There is a view that injury compensation leads to worse health, called the “compensation hypothesis.” This view that compensation is harmful has been used as an argument for reductions to compensation benefits, to influence judicial decisions, and to advise people that compensation payments will impede their recovery. After their review of the literature, these authors state:

            “There is no clear evidence to support the idea that compensation and its related processes lead to worse health.” Claiming “lawyer involvement leads to worse pain,” could also be interpreted as “worse pain increases the likelihood of lawyer involvement.”

            “It is important to ascertain whether statistically significant negative associations between compensation-related factors and health do indeed indicate that exposure to these factors leads to worse health, or whether they simply reflect the likelihood that people in comparatively worse health (eg, pain) are more likely to pursue compensation. Unless the latter possibility is considered, decisions to reduce compensation benefits may inadvertently disadvantage those who are in most need of assistance, which would be an undesirable (and unintended) policy consequence.”

            In November 2012, Natalie Spearing and colleagues extended their research on these topics with a study published in the Journal of Clinical Epidemiology, titled (3):

  • Research on injury compensation and health outcomes: Ignoring the problem of reverse causality led to a biased conclusion

            This study highlights the serious consequences of ignoring Reverse Causality Bias in studies on compensation-related factors and health outcomes. These authors evaluated Reverse Causality using a sophisticated mathematical assessment of compensation claims associated with recovery from neck pain (whiplash) after rear-end collisions.

            Of the 503 subjects who agreed to participate in the study, 80% developed neck pain within 7 days of collision (early whiplash). Sixty-five percent of those with early whiplash symptoms became claimants, while 35% of those with early whiplash symptoms were non-claimants. Neck pain at 24 months was selected as the primary health outcome. Neck pain severity was measured using the visual analogue scale (VAS) score (0–100).

            These authors state: “Although it is commonly believed that claiming compensation leads to worse recovery, it is also possible that poor recovery may lead to compensation claims—a point that is seldom considered and never addressed empirically.” And “When reverse causality is ignored, claimants appear to have a         worse recovery than non-claimants; however, when reverse causality bias is addressed, claiming compensation appears to have a beneficial effect on recovery.”

            Reverse Causality must be evaluated to “avert biased policy and     judicial decisions that might inadvertently disadvantage people        with compensable injuries.” And “Once reverse causality bias is addressed, people who claim compensation appear to experience a better recovery from neck pain at 24 months compared with non-claimants.”

            “The results of this study suggest that compensation claiming may not be disadvantageous to injured parties after all and that it may even have a beneficial effect,” because access to financial assistance and/or treatment may “indeed relieve pain and suffering. This is, after all, one of the motivations for compensating people who have sustained an insult to their health.”

            “This study serves as a reminder of the dangers of drawing causal interpretations from statistical associations when the causal framework is ambiguous. It establishes, empirically, that reverse causality must be addressed in studies on compensation-related factors and health outcomes.”

SUMMARY  

            These authors reject the hypothesis that the decision to claim compensation negatively affects recovery. In contrast, they show that people with worse health tend to claim compensation. Policies that restrict access to compensation benefits or legal advice may inadvertently disadvantage people who need financial or legal assistance. In addition, many injured people feel compelled to seek legal counsel because it is their belief that their insurance company is treating them unfairly, hindering them from obtaining the treatment they need to recover.

References

  1. Spearing NM, Connelly LB, Gargett S, Sterling M; Does injury compensation lead to worse health after whiplash?  A systematic review; Pain; June 2012;
Sunday
Apr012012

The Omega-6/Omega-3 Ratio and Innate Neurological Function

Dan Murphy, DC—

Private Practice of Chiropractic;
Diplomate American Board of Chiropractic Orthopedist;
Faculty Life Chiropractic College West;
Vice President ICA 2003-2009;

ICA Chiropractor of the Year 2009

INTRODUCTION

Chiropractors pride themselves on improving the function of the nervous system by improving spinal mechanical integrity. However, it is also know that optimal neurological function requires a narrow, innate balance of omega-6 / omega-3 fatty acids. A recent article by physician and geneticist Artemis Simopoulos explores this relationship, and I have reviewed her article below:

 

Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain Molecular Neurobiology October, 2011; Vol. 44; No. 2; pp. 203-215

  • ·      LA = linoleic acid (plant derived omega-6 fatty acid)
  • ·      ALA = alpha linolenic acid (plant derived omega-3 fatty acid)

Dr. Simopoulos cites a number of sources indicating that human beings evolved on a diet that had a ratio of omega-6 to omega-3 fatty acids (FA) of about 1/1. Today, Western diets may have a ratio 25/1. Western diets are deficient in omega-3 FA compared with the diet on which humans evolved and their genetic patterns were established.

Omega-6 and omega-3 FA are important components of practically all cell membranes. The omega-3 FA docosahexaenoic acid (DHA) is essential for the normal functional development of the brain and retina. DHA accounts for 40% of the membrane phospholipid FA in the brain.

The omega-3 FAs eicosapentaenoic acid (EPA) and DHA have an effect on membrane receptor function and even neurotransmitter generation and metabolism.

The balance of omega-6 and omega-3 FA is important for homeostasis and normal development throughout the life cycle.

 

KEY POINTS FROM THIS STUDY INCLUDE:

  1. Nutrition is an environmental factor that influences gene expression.
  2. Major changes have taken place in our diet over the past 10,000 years since the beginning of the Agricultural Revolution, but our genes have not changed.
  3. The major changes that have taken place in our diets in the past 10,000 years include:

a)     An increase in energy intake and decrease in energy expenditure;

b)    An increase in saturated fat;

c)     An increase in omega-6 fatty acids;

d)    An increase in trans-fatty acids;

e)     An increase in cereal grains;

f)     An increase in fruit and vegetable intake;

g)     A decrease in omega-3 fatty acid intake;

h)    A decrease in complex carbohydrate intake;

i)      A decrease in fiber intake;

j)      A decrease in protein;

k)    A decrease in antioxidants;

l)      A decrease in vitamin D;

m)   A decrease in calcium intake.

  1. The beneficial health effects of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were described first in the Greenland Eskimos who consumed a high seafood diet and had low rates of coronary heart disease, asthma, type 1 diabetes mellitus, and multiple sclerosis. Since that observation, the beneficial health effects of omega-3 fatty acids have been extended to include benefits related to cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, and mental health.”
  2. The change of omega-6/omega-3 ratio in the food supply of Western societies has occurred over the last 150 years.
  3. During evolution, omega-3 fatty acids were found in all foods consumed: meat, wild plants, eggs, fish, nuts, and berries.”
  4. Today in Western societies the omega-6/omega-3 ratio is very high due to the high intake of soybean oil, corn oil, sunflower, safflower, and linseed oil.
  5. The omega-6/omega-3 ratio is associated with normal “growth and development, as well as in the outcome of hypertension, cancer, arthritis, mental health, allergies and other autoimmune diseases,” as well as the “pathophysiology of atherosclerosis, inflammation, and aging.
  6. DHA is found in high amounts in the membranes of brain and retina and is critical for proper neurogenesis, neurotransmitter metabolism, neuroprotection and vision. The consumption of high amounts of DHA has been associated with multiple health benefits including brain and retinal development, aging, memory formation, synaptic membrane function, photoreceptor biogenesis and function, and neuroprotection. DHA is essential for pre-natal brain development.”
  7. Omega-3s cause apoptotic death in cancer cells whereas omega-6s allowed the cancer cells to continue to proliferate. 
  8. Diets with a high omega-6/omega-3 ratio may enhance the risk for both depression and inflammatory diseases.
  9. “Clinical studies show that cognitive performance improves with omega-3’s.”
  10. Omega-3’s can affect not only cognitive functions, but also mood and emotional states and may act as a mood stabilizer. Omega-3’s have beneficial effects in some neurological diseases in addition to the chronic fatigue syndrome.
  11. Omega-3 deficiency in childhood delays brain development, and produces irreversible effects, while the same deficiency in aging accelerates the deterioration of brain function.
  12. Omega-3 intake from ALA does not provide adequate intakes of EPA and DHA.
  13. Western diets are characterized by high omega-6 and low omega-3 fatty acid intake, whereas during the Paleolithic period when human’s genetic profile was established, there was a balance between omega-6 and omega-3 fatty acids. Therefore, humans today live in a nutritional environment that differs from that for which our genetic constitution was selected.”
  14. The balance of omega-6/omega-3 fatty acids is an important determinant in maintaining homeostasis, normal development, and mental health throughout the life cycle.”
  15. The AA/EPA ratio has been proposed as an index for the omega-6/omega-3 ratio.
  16. Omega-3 deficiency in the brain is associated with “decreased learning ability, with a lower synaptic vesicle density in the hippocampus; whereas, chronic administration of omega-3’s improves reference memory-related learning probably due to increased neuroplasticity of the neural membranes.”
  17. Cognitive performance improves with omega-3’s supplementation possibly due to increased hippocampal acetylcholine levels, the anti-inflammatory effects of omega-3’s, decreased risk of cardiovascular disease or increased neuroplasticity.
  18. Omega-3 fatty acids have positive effects in patients with dementia, schizophrenia, depression and other central nervous systems diseases.
  19. Omega-3 fatty acid supplementation could play a role in reduced hostility and violence.
  20. In carrying out clinical intervention trials, it is essential to increase the omega-3 and decrease the omega-6 fatty acid intake in order to have a balanced omega-6 to omega-3 intake.”
  21. In humans, the brain is the most outstanding organ in biological development: it follows that the priority is brain growth and development, and in the brain the balance between omega-6 and omega-3 PUFA metabolites is close to 1:1. This ratio should be the target for human nutrition.
  22. The ratio of omega-6/omega-3 fatty acids in the brain between 1:1 and 2:1 is in agreement with the data from the evolutionary aspects of diet and genetics.
  23. “A ratio of 1:1 to 2:1 omega-6/omega-3 fatty acids should be the target ratio for health.”

 

COMMENTS FROM DAN MURPHY

The omega-6/omega-3 fatty acid ratio (AA/EPA) is innately critical for brain function, heart health, immunity, joint health, pain syndromes and more. I believe that everyone should have the AA/EPA ratio tested to see if they are in the “target ratio” of 1-2/1, AA/EPA.

Several labs offer testing of the AA/EPA ratio. The test is called Bloodspot Fatty Acids 0241. The test is a finger prick draw, not venipuncture. If you would like information on the lab I personally recommend, contact me at dan@danmurphydc.com.

Some nutritional companies offer more optimal ratios of ALA, EPA, DHA, and GLA. If you would like information on the omega-3 oils I personally recommend and take for myself, contact me at dan@danmurphydc.com.

The target ratio’s of EPA/DHA is different for children and adults. To achieve their “target ratio” most adults need to consume 3,000 mg/day of EPA+DHA